Prevalence of Allergy to Mosquitoes and Association with Asthma as well as with allergic diseases in Children of Havana
Keywords:
hypersensitive, Culicidae, asthma, children.Abstract
Introduction: The increase in mosquito infestation, as well as the incidence of asthma and atopy, is a worldwide phenomenon. In Cuba, both events are health concerns, but this relationship has been little studied.
Objective: To identify the prevalence of allergy to mosquitoes, as well as its possible association with asthma and other allergic diseases in children of Havana.
Methods: Cross-sectional study with 857 six-year-old children living in Havana, whose data were taken from the database of the study Historia natural de la sibilancia en niños de La Habana [Natural history of wheezing in children of Havana]. An International Study of Asthma and Allergies of Childhood (ISAAC) questionnaire was applied. Data on asthma and allergic diseases were collected. The skin prick test for allergies was considered positive (Aedes aegypti, Culex, Anopheles) if the wheal diameter was over or equal to 3 mm above negative control. Current allergy to mosquitoes was shown, based on the previous history of medical diagnosis plus positive skin prick test results. Dichotomous logistic regression was used to identify association.
Results: A prevalence of sensitized patients was found, accounting for 35.8%. A history of allergy to mosquitoes was represented in 42.6%, while current allergy to mosquitos was found in 14.2%. This diagnosis is associated with asthma (PR 1.29, 95% CI: 1.05-1.58), eczema (PR 1.41, 95% CI: 1.16-1.71), rhinoconjunctivitis (PR: 1.54, 95 CI %: 1.22-1.93), but not with allergic rhinitis.
Conclusions: Mosquito allergy is a health concern in Havana and is associated with asthma and allergic diseases. Vector control interventions will be necessary in order reduce the development of these diseases.
Downloads
References
Ortega Casanueva C. Alergia a la picadura de insectos. Pediatr Integral 2013;XVII(9):628-36. [consultado 3 Julio 2021] Available from: https://www.pediatriaintegral.es/numerosanteriores/publicacion-2013-11/alergia-la-picadura-de-insectos/
Crisp HC, Johnson KS. Mosquito allergy. Ann Allergy Asthma Immunol. 2013; 110(2):65-9. doi:10.1016/j.anai.2012.07.023.
Mohd A. Kausar, Vannan K. Vijayan, Surendra K. Bansal, Bala K. Menon, Maansi Vermani, Mahendra K. Agarwal. Mosquitoes as sources of inhalant allergens: Clinico immunologic and biochemical studies. J Allergy Clin Immunol 2007;120(5):1219-21. [consultado 3 Julio 2021] Available from: http://www.uoh.edu.sa/facultymembers/en/MA.KAUSAR/Documents/Adnan%0Kausar%20CV.pdf
Cantillo JF, Puerta L, Pushalska P, Lafosse-Marin S, Fernandez-Caldas E, Subiza. Allergenome characterization of the mosquito Aedes aegypti. Allergy 2017;72(10):1499-1509 doi: 10.1111/all.13150
Kumar R, Kumar M, Bisht I, Singh K. Prevalence of aeroallergens in patients of bronchial asthma and/or allergic rhinitis in India based on skin prick test reactivity. Indian J Allergy Asthma Immunol 2017;31(2):45-55. [consultado 3 Julio 2021] Available from: http://www.ijaai.in/text.asp?2017/31/2/45/215834.
Kraemer MUG, Sinka ME, Duda KA, Mylne AQN, Shearer FM, Barker CM, et al. The global distribution of the arbovirus vectors Aedes aegypti and Ae. Albopictus. Ecology Epidemiology and Global Health. 2015;4:e08347 doi: 10.7554/eLife.08347
Barne C, Alexis NE, Bernstein JA, Cohn JR, Demain JG, Horner E, et al. Climate change and our environment: the effect on respiratory and allergic disease. J Allergy Clin Immunol Pract Mar 2013;1(2):137-41. doi: 10.1016/j.jaip.2012.07.002
Cuevas Hernández MM, Arías Hernández RM, Acuña Aguilarte P, Chichay Torres L. Inmunoterapia con extracto de mosquito en niños con prúrigo por picaduras de este insecto. FDC [Internet] 2009 [consultado 9 sept 2020];3(1): [aprox. 4 p.]. Disponible en: http://bvs.sld.cu/revistas/fdc/vol3_1_09/fdc05109.htm
Dirección de Registros Médicos y Estadísticas de Salud. Anuario Estadístico 2017 [Internet]. La Habana: Ministerio de Salud Pública; 2017 [consultado 9 Sept 2020]. Disponible En: http://files.sld.cu/dne/files/2017/04/Anuario_2017_electronico-1.pdf
Venero Fernández SJ, Suárez-Medina R, Mora Faife EC, García García G, Valle Infante I, Gómez-Marrero L, et al. Risk factors for wheezing in infants born in Cuba. QJM. 2013 Nov;106(11):1023-9. doi:10.1093/qjmed/hct143
Venero-Fernández SJ, Varona Pérez P, Fabret Ortiz D, Suárez Medina R, Bonet Gorbea M, Molina Esquivel E, Romero Placeres M. Bronchial asthma and rhinitis in schoolboys from Havana City, 2001 to 2002. Revista Cubana de Higiene y Epidemiología. 2019;47(1):0-0 [consultado 3 Junio 2021] Disponible en: http://www.inhem.sld.cu/boletin%20infohem/boletin19.htm.
Varona Pérez P, Fabré Ortiz DE, Venero Fernández SJ, Suárez Medina R, Molina Esquivel E, Romero Placeres M. Rinitis alérgica, prevalencia y factores de riesgo en adolescentes cubanos. Rev Cub Hig Epid. 2014;52(3):330-345. [consultado 3 Junio 2021] Disponible en: http://scielo.sld.cu/pdf/hie/v52n3/hig06314.pdf
Varona Pérez P, Fabré Ortiz D, Águila de la Coba R, Corona B, Venero-Fernández S, Suárez-Medina R. Prevalencia de síntomas de dermatitis atópica en niños y adolescentes en La Habana (2002-2003). Rev Cub Med Gen Integ. 2012;28(1):42-51. [consultado 3 Junio 2021] Disponible en: http://scielo.sld.cu/pdf/mgi/v28n1/mgi06112.pdf
Fundora-Hernández H, Suarez-Medina R, Venero-Fernandez S, Mora-Faife E, García-García G, del Valle-Infante I, et al. What are the main environmental exposures associated with elevated IgE in Cuban infants? A population-based study. Tropical Medicine and International Health. 2014;19(5):545-54. [consultado 3 Junio 2021] Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309505/
Venero-Fernandez S, Fundora-Hernández H, Batista-Gutierrez L, Suarez Medina R, Mora Faife E, Valle-Infante I, et al. The association of low birth weight with serum C reactive protein in three year old children living in Cuba: A population-based prospective study. Am J Human Biol 2016:1-9 doi.10.1002/ajhb.22936.
Oppenheimer J, Durham S, Nelson H, Wolthers OD. Allergy Diagnostic Testing. World Allergy Organization. Nov 2007. [on line] [consultado 3 Julio 2021] Available from: https://www.worldallergy.org/education-and-programs/education/allergicdisease-resource-center/professionals/allergy-diagnostic-testing
Malling HJ. Methods of skin testing. Position paper: Allergen standardization and skin testing. The European Academy of Allergology and Clinical Immunology. Allergy 1993;48(14):55-56.
Martínez Borrego R, Pastrana Fundora F, Ramírez Albejés C, Naranjo Lorenzo M, Ortiz Regalado P. Morbilidad por afecciones dermatológicas, estudio estadístico territorial. Rev. Cuba. Pediatr. 1999;71(2):53-9
Rodríguez Hernández Y, Romero González P, Díaz González H, Jiménez Cardoso J. Morbilidad dermatológica pediátrica en consulta externa. Jatibonico. Abril 2004- marzo 2005. Gaceta Médica Espirituana 2007;9(1):0-0 [consultado 3 Julio 2021] Disponible en: https://redib.org/Record/oai_articulo1311862-morbilidad-dermatol%C3%B3gica-pedi%C3%A1trica-en-consulta-externa-jatibonico-abril-2004-marzo-2005
Del Pozzo-Magaña BR, Lazo-Langner A, Gutiérrez-Castrellón P, Ruiz-Maldonado R. Common dermatoses in children referred to a specialized pediatric dermatology service in Mexico: a comparative study between two decades. ISRN Dermatol. Oct 2012;2012(1):351603. doi:10.5402/2012/351603.
Yifeng GUO, Ping LI, Jianping TANG, Xiuping HAN, Wenkai ZONG, Hua WANG, et al. Prevalence of skin diseases in pre-school children aged 0-7 years in 12 cities of China. Chinese Journal of Dermatology 2017;50(11):790-794 doi:10.3760/cma.j.issn.0412-4030.2017.11.003
Balai M, Khare AK, Gupta LK, Mittal A, Kuldeep CM. Pattern of pediatric dermatoses in a tertiary care centre of South West Rajasthan. Indian J Dermatol. 2012;57(4):275–8. doi:10.4103/0019-5154.97665.
Rojas-Mogollón MA, Hernández-Neuta GE, Moncada-Alvarez LI, Quiñones ML, Renteria LL. Actividad de picadura de Culex quinquefasciatus, 1863 en Bogotá. Colombia Rev Fac Med. Jul 2013;61(3):261–6. [consultado 3 Julio 2021] Disponible en: http://www.scielo.org.co/pdf/rfmun/v61n3/v61n3a06.pdf
Laha A, Sarkar T, Dey D, Mondal P, Bhattacharya S, Moitra S, et al. Assessment of Hymenoptera and Non-Hymenoptera Insect Bite and Sting Allergy Among Patients of Tropical Region of West Bengal, India, Journal of Medical Entomology, January 2020;57(1):1–7 doi.org/10.1093/jme/tjz088
Castro-Almarales RL, Álvarez-Castelló M, Ronquillo-Díaz M, Rodríguez-Canosa JS y col. Sensibilidad y especificidad de la prueba cutánea por punción con dos concentraciones del extracto estandarizado de Culex quinquefasciatusen niños alérgicos. Rev Alerg Méx. ene-mar 2016;63(1):11-19 [consultado 3 Junio 2021] Disponible en: https://www.revistaalergia.mx/ojs/index.php/ram/article/view/114/288
Nazario S, Zaragoza R, Velázquez V, Ramos-Valencia G, Acantilado C, Rodríguez R, et al. Allergen Sensitivity (Mites, Insects, and Pets) in a Puerto Rican Population. P R Health Sci J 2012;31(1):24-28 [consultado 3 Junio 2021] Available from: http://prhsj.rcm.upr.edu/index.php/prhsj/article/view/634
González Díaz SN, Cruz AA, Sedó Mejía GA, Rojas Lozano AA, Valenzuela EA, Vidaurri Ojeda AC. Prevalence of reactions secondary to mosquito bites Aedes aegypti at en el Regional Center of Allergy and Clinical Immunology, University Hospital, de Monterrey, Nuevo Leon. Rev Alerg Mex. 2010 Mar-Apr;57(2):37-43 [consultado 3 Junio 2021] Disponible en: https://read.qxmd.com/read/20857628/-prevalence-of-reactions-secundary-to-mosquito-bites-aedes-aegypti-at-en-el-regional-center-of-allergy-and-clinical-immunology-university-hospital-de-monterrey-nuevo-leon
Sánchez J, Sánchez A, Cardona R. Exposición y sensibilización a insectos en pacientes alérgicos en el trópico. Biomédica Bogotá Aug. 2018;38(Supl.2):80-6. doi.org/10.7705/biomedica.v38i3.3801
Oka K, Ohtaki N, Igawa K, Yokozeki H. Study on the correlation between age and changes in mosquito bite response. J Dermatol 2018;45(12):1471-74. doi.org/10.1111/1346-8138.14688
Manuyakorn W, Itsaradisaikul S, Benjaponpitak S, Kamchaisatian W, Sasisakulporn C, Jotikasthira W, el al. Mosquito allergy in children: Clinical features and limitation of commercially-available diagnostic tests. Asian Pac J Allergy Immunol 2017;35(4):186-190 doi.10.12932/AP0842.
Lai1 CKW, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, the ISAAC Phase Three Study Group Global. Variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009;64:476-483 doi:10.1136/thx.2008.106609
Downloads
Published
How to Cite
Issue
Section
License
La Revista Cubana de Higiene y Epidemiologia protege los derechos de autor, y opera con una Licencia Creative Commons 4.0.(Licencia Creative Commons Atribución-No Comercial 4.0 Internacional (CC BY-NC 4.0).Al publicar en ella los autores permiten copiar y redistribuir el material en cualquier medio o formato; remezclar, transformar y crear a partir del material. Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia http://creativecommons.org/licenses/by-nc/4.0/ e indicar si se han realizado cambios. No puede utilizar el material para una finalidad comercial. No hay restricciones adicionales.
Los autores autorizan la publicación de sus escritos conservando los derechos de autoría, y cediendo y transfiriendo a la revista todos los derechos protegidos por las leyes de propiedad intelectual que rigen en Cuba, que implican la edición para difundir la obra.
Los autores podrán establecer acuerdos adicionales para la distribución no exclusiva de la versión de la obra publicada en la revista (por ejemplo, situarla en un repositorio institucional o publicarla en un libro), con el reconocimiento de haber sido publicada primero en esta revista.
